Study of Some Physiological and Biochemical Changes in Patients with Chronic Renal Failure (CRF) Undergoing Hemodialysis in Merzak region

Abstract

This study was conducted at Murzuq Central Hospital from 1/1/2017 to 2/12/2020 to evaluate the percentage of hemoglobin, hematocrit, platelets, triglycerides, cholesterol and liver function for renal failure patients undergoing hemodialysis, and the study included (32) patients with chronic renal failure, including 20 males and 12 females aged between 10-90 years, and the control group was (20) people without kidney failure.

The results of the study showed that renal failure led to a significant decrease (P<0.05) in the concentration of hemoglobin and hematocrit and platelet count and total white blood cell count compared to the control group. The results also showed a significant increase (P<0.05) in the proportion of neutral, single and eosinophilic white blood cells, while the percentage of lymphocytes decreased significantly  (P<0.05)  in the group of patients compared to control The results also showed a significant (p<0.05) increase in the percentage of neutral, single and acidic white blood cells, while the percentage of lymphocytes decreased significantly (P<0.05) in the group of patients compared to control, and the results showed a significant increase (P<0.05) in the concentration of triglycerides and total cholesterol. The results showed a significant increase (P<0.05) in the concentration of triglycerides and total cholesterol and a significant decrease (P<0.05) in the concentration of high-density lipoproteins (HDL) and the concentration of enzyme AST, ALT in patients with chronic renal failure compared to the control group.

According to these results, chronic renal failure is the cause of imbalance of most of the studied hematological and biochemical indicators.